(as of Oct 31)


As of Oct. 4, 2023

Friday, Nov 3, 2023


Opening Remark

Masayuki Yamamoto


1) Keynote Lectures

Chairpersons: Masayuki Yamamoto & Thomas W. Kensler
-9:35-10:20 (45 min) Masayuki Yamamoto
Sixth Environmental Stress Symposium on the KEAP1-NRF2 System Regulating the Molecular Basis of Oxidative Stress Response and Its Perturbation
-10:20-11:05 (45 min) Thomas W. Kensler
How Important is NRF2 for the Pharmacodynamic Action of “NRF2 Inducers"?

Co-sponsored by Chugai Pharmaceutical Co., Ltd.

11:05-11:25 Break


2) Session: Molecular Mechanisms of the KEAP1-NRF2 System Function

Chairperson: Donna D. Zhang
-11:25-11:55 (30 min) Hozumi Motohashi
NRF2 Buddy for Transcriptional Activation
-11:55-12:25 (30 min) Michael B. Major
Proximity Proteomic Analysis Reveals Mechanisms of KEAP1 Inactivation by Cysteine Modification and New Connections for NRF2 in Parkinson's Disease

12:25-13:55 Lunch time & Poster Discussion (ODD number)


2) Session: Molecular Mechanisms of the KEAP1-NRF2 System Function

Chairperson: Donna D. Zhang
-13:55-14:35 (40 min) Albena T. Dinkova-Kostova
Nrf2 depletion in the context of Keap1 loss-of-function leads to mitolysosome accumulation
-14:35-15:05 (30 min) Ken Itoh
Cross-talk of GCN1-GCN2 branch of ISR and Nrf2 pathway in environmental stress response
-15:05-15:35 (30 min) Elias S.J. Arnér
Selenium in control of ferroptosis – potential roles and cross-talk between glutathione peroxidases and thioredoxin reductases
-15:35-16:05 (30 min) Takafumi Suzuki
Molecular Basis of Stress Response by the KEAP1-NRF2 System

16:05-16:25 Break


2) Session: Molecular Mechanisms of the KEAP1-NRF2 System Function

Chairperson: Ken Itoh
-16:25-16:55 (30 min) Donna D. Zhang
From Antioxidant Defense to Iron Homeostasis: NRF2's Multifaceted Guard Against Ferroptosis
-16:55-17:15 (20 min) Youngtae Jeong
Keap1-Nrf2 pathway in the cancer therapeutic resistance and anti-tumor immunity
-17:15-17:35 (20 min) John D. Hayes
Inhibition of liver fibrosis by Nrf2: antagonism of Nrf2 by TGF-beta
-17:35-17:55 (20 min) Nobunao Wakabayashi
Forced Hepatic Expression of NRF2 or NQO1 Alleviates Hepatic Lipid Accumulation and Hepatocellular Damage in a Lipodystrophy Mouse Model
-17:55-18:15 (20 min)Tetsuro Ishii
Mechanisms underlying Nrf2 activation by non-lethal levels of hydrogen peroxide: roles of glutathione sensor neutral sphingomyelinase2, p38 and ERK MAP kinases and prolyl cis/trans isomerase Pin1

18:30- Welcome Reception @Cafeteria

Saturday, Nov 4, 2023


3) Session: The KEAP1-NRF2 System and Cancers

Chairperson: Hozumi Motohashi
-9:00-9:30 (30 min) Anna-Liisa Levonen
NRF2 and Cancer Immunity
-9:30-10:00 (30 min) Young-Joon Surh
Pseudohypoxic stabilization of HIF-1α through direct interaction with NRF2 in hepatocellular carcinoma
-10:00-10:30 (30 min) Gina M. DeNicola
Distinct Nrf2 signaling thresholds mediate lung tumor initiation and progression
-10:30-11:00 (30 min) Kate D. Sutherland
Identifying novel vulnerabilities to sensitise KEAP1 mutant lung adenocarcinoma to T cell mediated killing

11:00-11:20 Break


3) Session: The KEAP1-NRF2 System and Cancers

Chairperson: Anna-Liisa Leveon
-11:20-11:40 (20 min) Fumiki Katsuoka
Functional Characterization of CNC-sMAF Heterodimers by the Tethered Dimer Rescue System
-11:40-12:00 (20 min) Liam Baird
Immunoediting of KEAP1-NRF2 mutant tumours is required to circumvent NRF2-mediated immune surveillance
-12:00-12:30 (30 min) Thales Papagiannakopoulos
Uncovering Metabolic Bottlenecks in KEAP1-mutant Lung Cancer
-12:30-12:50 (20 min) Akira Kobayashi
NRF3: The NRF2-Related Transcription Factor Responding to Arginine Depletion in Cancer

12:50-14:20 Lunch time & Poster Discussion (EVEN number)


4) Session: The KEAP1-NRF2 System and Diseases

Chairperson: Keiko Taguchi
-14:20-14:50 (30 min) Jingbo Pi
NRF1 and NRF2 coordinate osteoclastogenesis and bone remodeling
-14:50-15:20 (30 min) Gerasimos Sykiotis
New roles of Keap1/Nrf2 signaling in thyroid gland function and thyroid pathophysiology
-15:20-15:40 (20 min) Mi-Kyoung Kwak
NRF2 and HIF-2α-induced cancer stem cell phenotypes in chronic hypoxic conditions

15:40-16:00 Break


4) Session: The KEAP1-NRF2 System and Diseases

Chairperson: John D. Hayes
-16:00-16:30 (30 min) Ian Copple
Pharmacology & toxicology of Nrf2 in the liver
-16:30-16:50 (20 min) Ana I. Rojo
Defining the role of the NRF2 transcription factor in synaptic maintenance in Alzheimer’s disease
-16:50-17:10 (20 min) Ioannis Trougakos
NRF2 in stress, ageing and disease
-17:10-17:30 (20 min) Florian A. Karreth
The small MAF transcription factor MAFG is a potent driver of melanoma
-17:30-17:50 (20 min) Masaki Hoshino
The efficacy of the novel NRF2 activator CH0924 for acute kidney injury

18:15- Round-Table Discussion @ ToMMo atrium

Sunday, Nov 5, 2023


5) Session: The KEAP1-NRF2 System and Drug Development

Chairperson: Antonio Cuadrado
-8:40-9:20 (40 min) Karen T. Liby
Developing therapies to target NRF2
Co-sponsored by Kyowa Kirin Co.,Ltd. -9:20-9:50 (30 min) Terry W. Moore
Non-Electrophilic NRF2 Activators Promote Wound Healing in Human Keratinocytes and Diabetic Mice and Demonstrate Selective Downstream Gene Targeting
-9:50-10:10 (20 min) Akihito Otsuki
ibSLS database: an integrated database for the exploration of environmental stress response during space flight

10:10-10:30 Break


5) Session: The KEAP1-NRF2 System and Drug Development

Chairperson: Albena T. Dinkova-Kostova
-10:30-10:45 (15 min) Anqi Zhang
Nrf2 Activation Improves Experimental Rheumatoid Arthritis
-10:45-11:00 (15 min) Sharadha Dayalan Naidu
Pharmacologic and genetic activation of Nrf2 confers anti-fibrotic effects
-11:00-11:15 (15 min) Aikseng Ooi
Sexual dimorphism of NRF2 target gene modulation
-11:15-11:30 (15 min) Xiaoxin Luke Chen
Small Molecule Screen Identifies Pyrimethamine as an Inhibitor of NRF2-driven Esophageal Hyperplasia
-11:30-12:00 (30 min) Antonio Cuadrado
Targeting the NRF2/beta-TrCP axis in liver disease


Closing Remark
Masayuki Yamamoto

12:15-13:30 Lunch


Public Lecture "Space & Health" >> see more details


Excursion >> see more details

Program at a glace

As of May 23, 2023

Nov 3rd Fri Nov 4th Sat Nov 5th Sun Nov 6th Mon
am Keynote Lectures Session Session Excursion
“Towards Building
the Future
of Healthcare”
Lunch Lunch Lunch
Session Session
pm Public Lecture
"Space & Health"
Sendai Station
night Welcome party
for all participants
Round-Table Discussion
for all participants
Poster Poster


As of May 23, 2023

Elias Arnér Karolinska Institutet
Ian M. Copple University of Liverpool
Antonio Cuadrado Autonomous University of Madrid
Gina M. DeNicola Moffitt Cancer Center
Albena T. Dinkova-Kostova University of Dundee
John D. Hayes University of Dundee
Tetsuro Ishii Tsukuba University
Ken Itoh Hirosaki University
Youngtae Jeong Daegu Gyeongbuk Institute of Science and Technology (DGIST)
Thomas W. Kensler Fred Hutchinson Cancer Research Center
Akira Kobayashi Doshisha University
Mi-Kyoung Kwak The Catholic University of Korea
Anna-Liisa Levonen University of Eastern Finland
Karen T. Liby Michigan State University
Michael B. Major Washington University in St. Louis
Terry W. Moore University of Illinois at Chicago
Hozumi Motohashi Tohoku University
Thales Papagiannakopoulos NYU Medical School
Jingbo Pi China Medical University
Ana Rojo Universidad Autónoma de Madrid
Young-Joon Surh Seoul National University
Kate Sutherland The Walter and Eliza Hall Institute of Medical Research
Gerasimos P. Sykiotis Université de Lausanne
Masayuki Yamamoto Tohoku University
Donna D. Zhang The University of Arizona